Lowering and Stabilizing PSA Levels in Advanced-prostate Cancer Patients With Oral Methioninase

نویسندگان

چکیده

Background/Aim: Methionine addiction is a general and fundamental hallmark of cancer due to the excess use methionine for transmethylation reactions, termed “Hoffman Effect”. has been shown be highly-effective target therapy by restriction with oral recombinant methioninase (o-rMETase) in preclinical studies, including patient- derived orthotopic xenograft (PDOX) mouse models cancer. A clinical study o-rMETase as supplement showed 70% reduction PSA levels patient bone-metastatic prostate Materials Methods: In present study, two advanced prostate-cancer patients took approximately one month. Results: One taking 38% second 20% reduction. Conclusion: shows promise treating

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ژورنال

عنوان ژورنال: Anticancer Research

سال: 2021

ISSN: ['0250-7005', '1791-7530']

DOI: https://doi.org/10.21873/anticanres.14958